The plant LINC complex at the nuclear envelope
نویسندگان
چکیده
منابع مشابه
Nuclear envelopathies: a complex LINC between nuclear envelope and pathology
Since the identification of the first disease causing mutation in the gene coding for emerin, a transmembrane protein of the inner nuclear membrane, hundreds of mutations and variants have been found in genes encoding for nuclear envelope components. These proteins can be part of the inner nuclear membrane (INM), such as emerin or SUN proteins, outer nuclear membrane (ONM), such as Nesprins, or...
متن کاملExploring the LINC to nuclear envelope spacing
L INC complexes do not maintain the space between nuclear membranes, except in cells exposed to mechanical stress, Cain et al. reveal. SUN proteins in the inner nuclear membrane and KASH proteins in the outer nuclear membrane form LINC complexes that regulate multiple processes by connecting the nucleoskeleton to the cytoskeleton. LINC complexes are also thought to maintain a uniform gap of ~50...
متن کاملAn unresolved LINC in the nuclear envelope.
The nuclear envelope segregates the nucleoplasm from the cytoplasm and is a key feature of eukaryotic cells. Nuclear envelope architecture is comprised of two concentric membrane shells which fuse at multiple sites and yet maintain a uniform separation of 30-50 nm over the rest of the membrane. Studies have revealed the roles for numerous nuclear proteins in forming and maintaining the architec...
متن کاملOuter nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture
Linker of nucleoskeleton and cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal force transduction. A few NE proteins have been found to regulate the LINC complex. In this study, we identify one, Kuduk (Kud), which can reside at the outer nuclear membrane and is required for the development of Drosophila melanogaster ovarian follicles and NE morpho...
متن کاملLINCing complex functions at the nuclear envelope
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements. The complexes are built from members of two evolutionary conserv...
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ژورنال
عنوان ژورنال: Chromosome Research
سال: 2014
ISSN: 0967-3849,1573-6849
DOI: 10.1007/s10577-014-9419-7